PKC
PKC (Protein kinase C) is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades.
The PKC family consists of fifteen isozymes in humans. They are divided into three subfamilies, based on their second messenger requirements: conventional (or classical), novel, and atypical.
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Ro 31-8220(Bisindolylmaleimide IX)甲磺酸盐是泛PKC抑制剂，对PKC-α，PKC-βI，PKC-βII，PKC-γ和PKC-ε的IC50分别为5 nM，24 nM，14 nM，27 nM和24 nM。
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Go 6983是一种pan-PKC抑制剂，作用于PKCα， PKCβ， PKCγ和PKCδ，IC50分别为7 nM， 7 nM， 6 nM和10 nM，对PKCζ作用稍弱，抑制PKCμ活性。
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Sotrastaurin(AEB-071)是PKCθ选择性抑制剂，Ki为0.22 nM。
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(-)-Epigallocatechin Gallate(EGCG)是多酚类黄酮抗氧化剂，能抑制端粒酶和DNA甲基转移酶，还能阻断EGF和HER-2的受体活性。
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Staurosporine (AM-2282)是一种有效的PKC抑制剂，作用于PKCα， PKCγ和PKCη时，IC50分别为2 nM， 5 nM和4 nM，对PKCδ(20 nM)， PKCε(73 nM)和PKCζ(1086 nM)作用效果稍弱。
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Ro 31-8220(Bisindolylmaleimide IX)甲磺酸盐是泛PKC抑制剂，对PKC-α，PKC-βI，PKC-βII，PKC-γ和PKC-ε的IC50分别为5 nM，24 nM，14 nM，27 nM和24 nM。
More
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Go 6983是一种pan-PKC抑制剂，作用于PKCα， PKCβ， PKCγ和PKCδ，IC50分别为7 nM， 7 nM， 6 nM和10 nM，对PKCζ作用稍弱，抑制PKCμ活性。
More
-
Sotrastaurin(AEB-071)是PKCθ选择性抑制剂，Ki为0.22 nM。
More
-
(-)-Epigallocatechin Gallate(EGCG)是多酚类黄酮抗氧化剂，能抑制端粒酶和DNA甲基转移酶，还能阻断EGF和HER-2的受体活性。
More
-
Staurosporine (AM-2282)是一种有效的PKC抑制剂，作用于PKCα， PKCγ和PKCη时，IC50分别为2 nM， 5 nM和4 nM，对PKCδ(20 nM)， PKCε(73 nM)和PKCζ(1086 nM)作用效果稍弱。
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